
高超,博士。研究领域为药物化学生物学,主要包括:靶向G-四链体结构的抗植物病毒、抗肿瘤和抗菌药物设计和筛选;综合运用分子生物学、化学生物学和结构生物学等多学科技术探索活性药物的作用机制。以第一作者或通讯作者在Nucleic Acids Research(2篇)、Journal of Agricultural and Food Chemistry、Pest Management Science、International Journal of Biological Macromolecules和LWT-Food Science and Technology等中科院一区的国际权威期刊上发表学术论文。
学习经历:
2017.09 - 2021.09 华中农业大学 农学博士
2015.09 - 2017.09 华中农业大学 农学硕士(提前攻博)
研究方向:
1. 基于核酸结构靶标,设计、筛选抗病毒、抗肿瘤和抗菌活性小分子;
2. 微生物源富硒产物活性评价及作用机制研究;
3. 有机硒类药物的靶标鉴定。
主要科研成果:
第一或通讯作者文章:
1. Gao, C#, Liu Z#, Hou, H.H#. Ding J, Chen X, Xie C, Song Z, Hu Z, Feng M, Mohamed HI, Xu S, Parkinson GN, Haider S, Wei D. BMPQ-1 binds selectively to (3+1) hybrid topologies in human telomeric G-quadruplex multimers. Nucleic Acids Res., 2020, 18;48(20):11259-11269. (IF = 16.7);
2. Zhai, Q.Q#., Gao, C#, Ding, J.Q.# Zhang Y, Islam B, Lan W, Hou H, Deng H, Li J, Hu Z, Mohamed HI, Xu S, Cao C, Haider SM, Wei D. Selective recognition of c-MYC Pu22 G-quadruplex by a fluorescent probe. Nucleic Acids Res., 2019,47(5), 2190-2204. (IF = 16.7,共同第1作者);
3. Wang M, Chen J, Xu Y, Wang Y, Mohamed HI, Wei D, Gao C. RHPS4 targeted the G-quadruplex of the 1a gene of Cucumber mosaic virus to inhibit viral proliferation. J. Agric. Food Chem. 2024, 72(45):25015-25022. (IF = 5.7)
4. Gao C, Wei S, Xu Y, Mohamed HI, Liu W, Wang Z, Wu W, Wang M, He Y. BRACO-19 targeted the G-quadruplex in the 3'UTR of the Cucumber mosaic virus 1a, 2b, and CP genes to inhibit viral proliferation. Pest Manag. Sci., 2025, DOI:10.1002/ps.8769.(IF = 3.8)
5. Gao C#, Deng J#, Anwar N, Umer M, Chen J, Wu Q, Dong X, Xu H, He Y, Wang Z. Molecular crowding promotes the aggregation of parallel structured G-quadruplexes. Int. J. Biol. Macromol. 2023, 240:124442. (IF = 7.7)
6. Wang Y#, Gao C#, Long P, Hu Z, Zhu L, Wang L, Shao Y, Xu H, Wang B, He Y. Dynamic changes of active substances of rice, Pueraria and yam fermentation by Monascus ruber. Lwt-Food Sci. Technol. 2023, 183:114925 (IF = 6.0,共同第1作者)